Donald Trump’s re-election in the 2024 US presidential election has reignited concerns about multilateralism and global health. During his first term (2017-2021), Trump demonstrated minimal commitment in multilateralism, as evidenced by his intent to withdraw from the WHO, proposed cuts to PEPFAR, and reduced global health contributions. His return to power risks destabilising global health financing, jeopardising the future of the Pandemic Agreement, and deepening inequities. By using exploratory research, this study explores the implications of Trump’s victory on Indonesia’s global health strategy. Since the COVID-19 pandemic, Indonesia has played a more active role in global health through initiatives such as the Pandemic Fund, Global Fund, and the Pandemic Agreement’s Group of Equity. Trump’s re-election could heighten structural challenges in global health and hinder Indonesia’s leadership. Our findings suggest the need for Indonesia to recalibrate its global health strategy, focusing on South-South cooperation and strengthening domestic capacities for global health diplomacy.